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Re: O/T: Fuck Cancer

Posted: Sat Nov 19, 2016 3:46 pm
by Blackwhite
Rough for him of course (but unsurprisingly quick given the mets), and probably for her too once she's processed it. Best of luck to both of you.

O/T: Fuck Cancer

Posted: Sat Nov 19, 2016 10:09 pm
by Ponte
Thanks, chaps. After the diagnosis my missus and her sister decided that the past was the past, put it to one side as he was still their dad and put some serious effort in being there for him. No point holding grudges. That has helped as regrets are at a minimum now.

Re: O/T: Fuck Cancer

Posted: Sat Nov 19, 2016 10:35 pm
by Blackwhite
Very healthy. That'll serve them both well no doubt.

Re: O/T: Fuck Cancer

Posted: Tue Dec 20, 2016 7:50 am
by Blackwhite
Good news corner: UK cancer death rates to fall by 15% by 2035 due to advances in research.

We're getting there (I realise some of you think this is all waste, or pointless: it isn't).

Re: O/T: Fuck Cancer

Posted: Tue Dec 20, 2016 8:09 am
by Billy Casper
I may or may not have missed the opportunity of such advancements by then, but don't let that detract from the positive news :thumbl:

Re: O/T: Fuck Cancer

Posted: Tue Dec 20, 2016 8:27 am
by Blackwhite
And while we're being positive: new prostate therapy showing great results and much reduced impact on potency and continence.

A drug activated by laser light successfully destroys early prostate cancer while avoiding side-effects that commonly occur with surgery, trial results have shown.

The new technique, called vascular-targeted photodynamic therapy (VTP), involves injecting a light-sensitive drug into the bloodstream. The drug is then “switched on” by laser pulses fired through optical fibres inserted into the prostate.

Of 196 men who received the treatment, about half showed no signs of the disease two years later, compared with 13.5% of those given standard care.

Because VTP targets only prostate tumours, it does not cause the long-term problems of impotence and urinary incontinence often associated with “radical” surgery or radiotherapy.

Lead investigator Professor Mark Emberton, consultant urologist at University College London hospital, said: “These results are excellent news for men with early localised prostate cancer, offering a treatment that can kill cancer without removing or destroying the prostate.

“This is truly a huge leap forward for prostate cancer treatment, which has previously lagged decades behind other solid cancers such as breast cancer.

“In 1975, almost everyone with breast cancer was given a radical mastectomy, but since then treatments have steady improved and we now rarely need to remove the whole breast.

“In prostate cancer, we are still commonly removing or irradiating the whole prostate, so the success of this new tissue-preserving treatment is welcome news indeed.”

Currently, men with low-risk localised prostate cancer are put under “active surveillance”, which means monitoring the disease but providing no treatment unless it becomes more severe.

In the trial consisting of 413 men, participants were randomly assigned either to VTP or active surveillance.

Only 6% of the VTP group later needed radical treatment, compared with 30% of active surveillance patients. VTP treatment also doubled the average time of cancer progression from 14 months to 28 months.

The trial, reported in the Lancet Oncology journal, was conducted across 47 treatment sites in 10 European countries, most of which were performing VTP for the first time.

Emberton said: “The fact that the treatment was performed so successfully by non-specialist centres in various health systems is really remarkable.

“New procedures are generally associated with a learning curve, but the lack of complications in the trial suggests that the treatment protocol is safe, efficient and relatively easy to scale up.

“We would also expect the treatment to be far more precise if we repeated it today, as technology has come a long way since the study began in 2011.

“We can now pinpoint prostate cancers using MRI (magnetic resonance imaging) scans and targeted biopsies, allowing a much more targeted approach to diagnosis and treatment.

“This means we could accurately identify men who would benefit from VTP and deliver treatment more precisely to the tumour.

“With such an approach, we should be able to achieve a significantly higher remission rate than in the trial and send nearly all low-risk localised prostate cancers into remission.

“We also hope that VTP will be effective against other types of cancer. The treatment was developed for prostate cancer because of the urgent need for new therapies, but it should be translatable to other solid cancers including breast and liver cancer.”

The drug used, WST11, is derived from bacteria at the bottom of the ocean. To survive with very little sunlight, the bugs have evolved to convert light into energy with high efficiency. This property was exploited to develop the drug, a compound that releases destructive tumour-busting “free radical” molecules when activated by laser light.

Gerald, a man aged in his 60s from Surrey, was one of the first patients to be treated with VTP under the care of Emberton.

He said: “The treatment ... changed my life. I’m now cancer-free with no side-effects and don’t have to worry about needing surgery in future. I feel so lucky to be in this position.

“I’ve met other men who had surgery - they had to stay in hospital for days whereas I could go home the next day, and one suffered from terrible incontinence which he found very distressing.

“I had some minor side-effects for a few weeks after the operation, but I’m back to normal now.”

Each year, more than 46,000 men in the UK are diagnosed with prostate cancer and 11,000 die from the disease.



Coins in tins, gents. Coins in tins.

Re: O/T: Fuck Cancer

Posted: Wed Jan 04, 2017 4:31 pm
by metalsmurf
metalsmurf wrote:
metalsmurf wrote:Not commented on this thread before, been kind of avoiding reading it. However it seems that cancer wants to fuck with my family wether I acknowledge it or not :roll:
Brother in law diagnosed with throat cancer Jan last year, responded very well to treatment etc doing well.
Mums sister diagnosed lung cancer Oct last year, died Dec.
Mum diagnosed liver cancer Jan this year, small tumour just had an ablation, if thats the correct term, to burn it away. Went well scan in 3 weeks to find out.
And finally I've got an appointment on Thursday to find out if i'm gonna join the one nut club :pale: :puker:
Fuck cancer...

Mums scan was inconclusive after the op so they booked her an MRI. She had a holiday booked and said fuck it, i'm going you can scan me when I get back in 4 weeks, this might be my last holiday. Scan was delayed when she got back but she got the all clear last week, thought i'd post some good news. :cheers:

And we're back on the bus. :(
Latest scan shows 2 more very small tumors, they're (the hospital) not sure if it was a bit missed thats grown or new growth. She's going in 17th for a repeat of the ablation procedure, fingers crossed.

Re: O/T: Fuck Cancer

Posted: Wed Jan 04, 2017 4:46 pm
by Devi
Mrs Devi had a mid-December scare, but tests thankfully found nothing other than 'fatty tissue'. (I have yet to refer to it as that to her face)...

Anyway. Turns out finger crossing can perhaps help, Metal, so consider mine crossed for your mum.

Re: O/T: Fuck Cancer

Posted: Wed Jan 04, 2017 4:47 pm
by Ponte
Aye, fingers crossed here, mate.

Re: O/T: Fuck Cancer

Posted: Wed Jan 04, 2017 4:47 pm
by metalsmurf
Thanks chaps

Re: O/T: Fuck Cancer

Posted: Wed Jan 04, 2017 4:53 pm
by Blackwhite
They may have been part of the last lot, but just too small to pick up on that first scan (it's hard to see perfectly, signal and noise etc.). Hopefully will ablate cleanly, the best of luck to you all. Especially to her. Think positive. Forza.

Re: O/T: Fuck Cancer

Posted: Wed Jan 04, 2017 4:56 pm
by metalsmurf
Yes thats my thinking, because it was under the surface there was quite a bit of scar tissue so hard to see. I always stay positive, thats why i'm still shelling out for a ST after last seasons shit show :lol:

Re: O/T: Fuck Cancer

Posted: Wed Jan 04, 2017 5:02 pm
by Blackwhite
metalsmurf wrote:I always stay positive, thats why i'm still shelling out for a ST after last seasons shit show :lol:

:mrgreen: Charitable too then mate. You're a saint :king:


Important for her too, of course :thumbl:

Re: O/T: Fuck Cancer

Posted: Fri Jan 06, 2017 9:52 pm
by eric olthwaite
BW - Mrs O's aunt is badly with bowel and secondary liver cancer. She's in line for some apparently newish rareish treatment called SIRT. Is that a good thing?

Re: O/T: Fuck Cancer

Posted: Fri Jan 06, 2017 10:43 pm
by Blackwhite
Quick answer mate is that it looks like a smart approach to the liver mets and is in trial. Not my area so sadly I know nothing about how well it works.

Am sat kicking it with wife, will browse pubmed while we chat and get back shortly.

Re: O/T: Fuck Cancer

Posted: Sat Jan 07, 2017 9:24 am
by Blackwhite
Eric, took a look last night for reviews considering SIRT trial data - the main one I saw is here https://www.ncbi.nlm.nih.gov/pubmed/27690234

Caveats abound, but the historical trials seem to suggest somewhere between no/little and moderate benefit: certainly not inferior, though. Worth starting that the newer trials may be doing something differently and their responses may be better than previous studies.

If you want me to take a look at the patient info privately and advise on what the study is, happy to do so as Devil/detail. (Randomisation means she'll want to be happy with whatever arm she gets put into: the control arm for SIRT is probably going to be arterial chemo alone, as above.)

Re: O/T: Fuck Cancer

Posted: Sat Jan 07, 2017 10:02 am
by Tycipa
Good news story.
My uncle had a PSA of something like 250 plus back in March last year. Prostate cancer was diagnosed. Straight into treatment and bingo, 2nd of December he got the all clear.

Re: O/T: Fuck Cancer

Posted: Sat Jan 07, 2017 10:15 am
by Blackwhite
Great news, Tycipa. As I posted above, prostate treatment is getting better and better, for efficacy and side-effects. And here as everywhere, rapid diagnosis and treatment is key. Get a health check if you've not had one in yonks (writes the hypocrite who's never had one :lol: ).

Re: O/T: Fuck Cancer

Posted: Sat Jan 07, 2017 10:26 am
by Tycipa
One of the side effects as we all know is chemo makes your hair fall out. My uncle hasn't aged much, still a bit of a Peter Pan even at 64 years old, was concerned about this. Apparently he wore some sort of cap which freezes the hair follicles prior to each treatment. He said it hurt like hell but he didn't lose a hair. He seemed more chuffed with that than the all clear.

Re: O/T: Fuck Cancer

Posted: Sat Jan 07, 2017 10:51 am
by Blackwhite
The hair loss thing... Targeted therapies don't have this side-effect, but sadly we don't have such therapies for all cancers yet.

The partner of the brother in law who died summer just gone is under chemo for her breast tumour (they found a couple months after he died - life's like a box of bullshit etfc.) She shaved her head in readiness, has a wig selection to suit her mood and try to be a bit fabulous about it... So hard for women. I don't know if she was offered the cap device - she'd probably just say no, buzz cut and get on with it...

Did know a lad who survived childhood lymphoma who had straight hair until chemo, then thick pubehead curls after. He minded this less than dying.