O/T: Fuck Cancer

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eric olthwaite
Joined: Mon Feb 11, 2008 10:14 pm
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Re: O/T: Fuck Cancer

Postby eric olthwaite » Sat Jan 07, 2017 10:59 am

Blackwhite wrote:Eric, took a look last night for reviews considering SIRT trial data - the main one I saw is here https://www.ncbi.nlm.nih.gov/pubmed/27690234

Caveats abound, but the historical trials seem to suggest somewhere between no/little and moderate benefit: certainly not inferior, though. Worth starting that the newer trials may be doing something differently and their responses may be better than previous studies.

If you want me to take a look at the patient info privately and advise on what the study is, happy to do so as Devil/detail. (Randomisation means she'll want to be happy with whatever arm she gets put into: the control arm for SIRT is probably going to be arterial chemo alone, as above.)


Cheers.

Mother's sister and not that close at all TBH. We were just curious about general prognosis as the MIL lost her other sister a year or two back and is a bit down about this.

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Blackwhite
Joined: Sun Feb 24, 2008 1:07 am
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Re: O/T: Fuck Cancer

Postby Blackwhite » Sat Jan 07, 2017 11:29 am

Well Eric, there the best thing is to not advise poorly based on a lack of knowledge of her situation, tumour staging etc. All I can do is point you at pages designed to offer some info on the ranges which might apply: for instance the ACS pages are good (I imagine PTBL is bookmarking these pages as we speak). They give the right caveats and context.

Her letters will give her grade, if she's willing to share that info. But bear in mind that the liver is very operable, that's why they're suggesting blasting bits that have mets from the primary, she'll just George Best it past the loss of those bits. Prognosis might be very good these days. Let's hope so, eh?

http://www.cancernetwork.com/colorectal ... r-be-cured

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203357/



Edit: forgot to say, it might be that the good bit if the trial is not the SIRT. There was mention of combos with antibody therapies (name will end in -mab) or small molecule drugs (name well end in -nib). These could be brand new, again, patient info pack will explain.
You know, I'm sick of following my dreams, man. I'm just going to ask where they're going and hook up with 'em later.

Wakefield White
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Re: O/T: Fuck Cancer

Postby Wakefield White » Sat Jan 14, 2017 12:37 pm

What about this then BW seems fairly miraculous...

http://www.bbc.co.uk/news/uk-england-nottinghamshire-38575256

My wife's old man was diagnosed with small cell prostate cancer in January 2010, never heard of 'small cell' before then, but now understand it to mean the difference between a battle and an inevitability. The lovely old sod only made it to August 2010.

Glad this lady is having more luck!
Fuck you Rod Liddle, fuck you in your cunting fuckface you fucking third division cunt!
(courtesy of Ponte)

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Blackwhite
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Re: O/T: Fuck Cancer

Postby Blackwhite » Sat Jan 14, 2017 3:02 pm

It's very exciting stuff immunotherapy. It's made an appearance in the thread already a few times, here and a couple of posts below, here, here, here, and here in response to you :mrgreen: which also has some info from Devi's mate, again here, and recently here hot from the research talks.

The drug in the link you posted today is a monoclonal antibody (name ends -mab) that blocks a signal that tells immune killer cells to shut down. This allows them to attack the tumour because, critically, it looks weird to them. Non-self. But the tumour can make these blockers,and shut down any killer cell that gets close. These drugs and a whole bunch of others stop that, and unleash the immune system on the tumour. Other approaches train the patient's cells to recognise the tumour, and put them back in.

Combinations of these approaches are in trials, as are single approaches from just about every drug company. A huge race to market. Several of these drugs have just recently become first-line therapies for some cancers, and more are on the way as the data rolls in. If I had a tumour I'd get on a trial of this stuff. When it works - and it's early days for working out what works best, it's very complex - but when it works, it can be insanely effective. Images out there in the literature of people with huge disseminated tumours in their "compassionate use" phase of their cancer, after failing everything else, having their tumour shrink away til it's operable.

Watch this stuff. It's the future, or part of it.
You know, I'm sick of following my dreams, man. I'm just going to ask where they're going and hook up with 'em later.

Wakefield White
Joined: Mon Feb 11, 2008 11:57 pm
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Re: O/T: Fuck Cancer

Postby Wakefield White » Sat Jan 14, 2017 4:52 pm

Blackwhite wrote:It's very exciting stuff immunotherapy. It's made an appearance in the thread already a few times, here and a couple of posts below, here, here, here, and here in response to you :mrgreen: which also has some info from Devi's mate, again here, and recently here hot from the research talks.



Oh I'm well aware I've asked about it before, it just seems to be that this area is moving so fast, there's some new good news story every week!

Long may it continue!
Fuck you Rod Liddle, fuck you in your cunting fuckface you fucking third division cunt!
(courtesy of Ponte)

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Blackwhite
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Re: O/T: Fuck Cancer

Postby Blackwhite » Sat Jan 14, 2017 4:57 pm

Sorry, didn't mean to be shitty about it, was just thinking it made sense to link it all together for the benefit of anyone that thought it was just a minor thing, as the links cover a variety of approaches and settings.

You're absolutely bang on, that said. It really is moving very fast indeed.

It is quite an exciting time TBH. Haven't been so excited since gleevec.
You know, I'm sick of following my dreams, man. I'm just going to ask where they're going and hook up with 'em later.

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Blackwhite
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Re: O/T: Fuck Cancer

Postby Blackwhite » Sat Jan 21, 2017 10:18 am

If you or someone you know has suspected prostate cancer, ask for MRI.
You know, I'm sick of following my dreams, man. I'm just going to ask where they're going and hook up with 'em later.

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metalsmurf
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Re: O/T: Fuck Cancer

Postby metalsmurf » Sat Jan 21, 2017 4:28 pm

Update on the mother, ablative procedure went well. There were 2 bits, removed the larger, the smaller was quite close to the lung and very small so has been left at the mo. Hardly any post procedure pain this time and home the day after. :)
Because a thing seems difficult for you, do not think it impossible for anyone to accomplish.

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Blackwhite
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Re: O/T: Fuck Cancer

Postby Blackwhite » Sat Jan 21, 2017 4:48 pm

Excellent news, hope she mends up well :thumbl:
You know, I'm sick of following my dreams, man. I'm just going to ask where they're going and hook up with 'em later.

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AndyPaul
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Re: O/T: Fuck Cancer

Postby AndyPaul » Sun Jan 22, 2017 12:09 pm

Great stuff mate

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Devi
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Re: O/T: Fuck Cancer

Postby Devi » Fri Mar 31, 2017 7:28 am

My mate's 12 year old girl just been diagnosed with secondary lung cancer, after three years in remission from Ewings Sarcoma, that resulted in the removal of her femur.
Having had emergency chemotherapy to get through that, the family are now asking for funds on just giving.

We are setting this fund up to pay for her therapies outside of the NHS.
These will include top quality nutrition, specialised supplements, Ozone Therapy and counselling as well as homeopathy, energetic healing and other natural and hugely effective immune-enhancing interventions for her body, mind and spirit.


Ozone? Homeopathy? Energetic healing?

Is it wrong I just banged my head against the wall? AIBAC?

:cry:
I like it. What is it?

Wakefield White
Joined: Mon Feb 11, 2008 11:57 pm
Location: t'other side o't hills

Re: O/T: Fuck Cancer

Postby Wakefield White » Fri Mar 31, 2017 7:39 am

They're just desperate to do anything and everything to save their little girl, if that involves clutching at a few straws so that they don't have to wonder, what if? So be it! (As long as it isn't harmful)
Fuck you Rod Liddle, fuck you in your cunting fuckface you fucking third division cunt!
(courtesy of Ponte)

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Blackwhite
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Re: O/T: Fuck Cancer

Postby Blackwhite » Fri Mar 31, 2017 8:01 am

So long as they're not taking her out of conventional therapy, probably just ok.

But if they want to stimulate her immune system, there​ are better options (checkpoint inhibitor trials may be open, I've not looked). I suspect her prognosis is grim either way but i don't know.

Edit for clarity: they're crazy with worry and none of it will help (bar perhaps the nutrition).
You know, I'm sick of following my dreams, man. I'm just going to ask where they're going and hook up with 'em later.

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MightyWhite
Joined: Mon Feb 11, 2008 11:38 am
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O/T: Fuck Cancer

Postby MightyWhite » Fri Mar 31, 2017 9:46 am

Yeah, I can only imagine what potions and witchcraft I'd be turning to if one of my two were diagnosed with such a thing. It's pretty much the worse thing I can ever imagine happening (save perhaps for them being snatched, a la MM).

In other news, my 80 year old grandma has just been diagnosed with pancreatic cancer. Due to go for chemo to try and keep it at bay for a bit but obviously the writing is very much on the wall with this variety. It's made even more depressing by the fact that she's still going strong in spite of her age - still going dancing every week, still cleaning the house from top to bottom every week, etc. Ordinarily you'd think she would have at least another 10-15 years left in her.

Like all folk of that vintage she's very pragmatic about the situation. But as is so often the case it's those around the affected person that get hit the hardest. My grandad is in absolute bits over the situation and that's really tough to see.

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Ponte
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Re: O/T: Fuck Cancer

Postby Ponte » Fri Mar 31, 2017 10:49 am

MightyWhite wrote:Yeah, I can only imagine what potions and witchcraft I'd be turning to if one of my two were diagnosed with such a thing. It's pretty much the worse thing I can ever imagine happening (save perhaps for them being snatched, a la MM).

In other news, my 80 year old grandma has just been diagnosed with pancreatic cancer. Due to go for chemo to try and keep it at bay for a bit but obviously the writing is very much on the wall with this variety. It's made even more depressing by the fact that she's still going strong in spite of her age - still going dancing every week, still cleaning the house from top to bottom every week, etc. Ordinarily you'd think she would have at least another 10-15 years left in her.

Like all folk of that vintage she's very pragmatic about the situation. But as is so often the case it's those around the affected person that get hit the hardest. My grandad is in absolute bits over the situation and that's really tough to see.


My Grandma was diagnosed with the same, 4 years ago. 'A doctor and someone else' gave her the news and said they would be in touch regarding options. Nobody has mentioned it since, doctors etc. She hasn't spoken to them about it. She's still here (aged 88).

Bizarre situation, really.
You agree not to post any abusive, obscene, vulgar, slanderous, hateful, threatening or sexually-orientated material. Doing so may lead to you being immediately and permanently banned.
Hmmm.

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Blackwhite
Joined: Sun Feb 24, 2008 1:07 am
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Re: O/T: Fuck Cancer

Postby Blackwhite » Fri Mar 31, 2017 12:25 pm

What?


That needs following up, Ponte. It may be that the message was missed or dropped along the way. If they had no intent to treat that should've been communicated more clearly, ie she should be aware of it and agree (often preferable in older folks).

She's a tough old bird though, clearly!
You know, I'm sick of following my dreams, man. I'm just going to ask where they're going and hook up with 'em later.

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Ponte
Joined: Mon Feb 11, 2008 9:36 am
Location: Between a rock and a hard place.

Re: O/T: Fuck Cancer

Postby Ponte » Fri Mar 31, 2017 2:18 pm

Blackwhite wrote:What?


That needs following up, Ponte. It may be that the message was missed or dropped along the way. If they had no intent to treat that should've been communicated more clearly, ie she should be aware of it and agree (often preferable in older folks).

She's a tough old bird though, clearly!


She has had no ill effect from it whatsoever. All I can think is that she didn't understand properly as surely something would have been mentioned about her condition by someone in the 4 years following. Even a missed or dropped message would have something somewhere in here records?
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Hmmm.

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Blackwhite
Joined: Sun Feb 24, 2008 1:07 am
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Re: O/T: Fuck Cancer

Postby Blackwhite » Fri Mar 31, 2017 3:05 pm

Either way, maybe someone should take her down there and clarify. They'll give out nowt until she's there.
You know, I'm sick of following my dreams, man. I'm just going to ask where they're going and hook up with 'em later.

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Ponte
Joined: Mon Feb 11, 2008 9:36 am
Location: Between a rock and a hard place.

Re: O/T: Fuck Cancer

Postby Ponte » Fri Mar 31, 2017 3:14 pm

Blackwhite wrote:Either way, maybe someone should take her down there and clarify. They'll give out nowt until she's there.

Aye, my old man was there originally but he's batshit as it is. I think I may need to have a chat.
You agree not to post any abusive, obscene, vulgar, slanderous, hateful, threatening or sexually-orientated material. Doing so may lead to you being immediately and permanently banned.
Hmmm.

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eric olthwaite
Joined: Mon Feb 11, 2008 10:14 pm
Location: Over there, behind that bush

Re: O/T: Fuck Cancer

Postby eric olthwaite » Tue Apr 11, 2017 11:19 am

Mrs O's auntie will probably go today or tomorrow. Can't remember where it started but she's got it everywhere now and there's been nothing they can do for a while. Wife's OK with it but her ma's struggling: she's now only got her two sisters and one's in Oz with dementia. Circumstances are all very similar to when her husband (ie Mrs' dad) died though, so it isn't easy.

Funny thing though - we realised when we were talking about about it last night that almost everyone in both branches of the wife's family has died of cancer. Whereas I don't think I have a single relative whose death has been caused by cancer; they've all gone from heart attacks / heart conditions / strokes.

I know it can't all be genetic, but it does seem weird. Good to know how we'll both go, anyway :thumbl:


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